Blar i forfatter "Alves Gama, Joao Pedro"

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    • Host dependent maintenance of a blaNDM-1-encoding plasmid in clinical Escherichia coli isolates 

      Alves Gama, Joao Pedro; Kloos, Julia Maria; Johnsen, Pål Jarle; Samuelsen, Ørjan (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-09)
      Dissemination of bacterial clones carrying plasmid-mediated resistance genes is a major factor contributing to the increasing prevalence of antibiotic resistance. Understanding the evolution of successful clones and the association to mobile resistance elements are therefore crucial. In this study, we determined the sequence of a 145 kb IncC multi-drug resistance plasmid (pK71-77-1-NDM), harbouring ...

    • Interactions between plasmids and other mobile genetic elements affect their transmission and persistence 

      Dionisio, Francisco; Zilhão, Rita; Alves Gama, Joao Pedro (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-14)
      Plasmids are genetic elements that play a role in bacterial evolution by providing new genes that promote adaptation to diverse conditions. Plasmids are also known to reduce bacterial competitiveness in the absence of selection for plasmid-encoded traits. It is easier to understand plasmid persistence when considering the evidence that plasmid maintenance can improve during co-evolution with the ...